Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series

Psoriasis vulgaris flare during efalizumab therapy does not preclude future use : Case

Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series

BACKGROUND Newer biological therapies for moderate-to-severe psoriasis are being used more frequently, but unexpected effects may occur. CASE PRESENTATIONS We present a group of 15 patients who developed inflammatory papules while on efalizumab therapy (Raptiva, Genentech Inc, anti-CD11a). Immunohistochemistry showed that there were increased CD11b+, CD11c+ and iNOS+ cells (myeloid leukocytes...

Bullous pemphigoid occurring during efalizumab treatment for psoriasis: a paradoxical auto-immune reaction?

ELISA test (titer: 99 and 112 units, respectively). A side effect of efalizumab was suspected, and this medication was discontinued. The search for other auto-immune complications proved negative with absence of antinuclear antibodies, rheumatoid factor, other haematological disturbances and a negative Coombs’ test. The patient was initially treated with highly potent topical steroids (clobetas...

Efalizumab rebound response to a sequential therapy of infliximab followed by efalizumab.

weak response after 10 days of ciclosporin and the immediate need to control the systemic disease. After 4 weeks, the patient was free of pustules but a slight erythema was still present. At week 14, the patient was free of lesions, and, after the 5th infusion, she requested the suspension of infliximab. Efa lizumab was reintroduced with the maintenance of the excellent results (PASI-100) until...

Palmoplantar pustular psoriasis: successful therapy with efalizumab after non-response to infliximab.

Palmoplantar pustular psoriasis (PPP) is a chronic inflammatory skin condition mainly characterized by recurrent eruptions of sterile pustules on erythematous skin; hyperkeratosis and fissures on the palms and soles are additional clinical features. Treatment options for PPP are unsatisfactory. We present a patient with a typical course of PPP that had previously received a broad range of topic...